Chen, ManNiestemski, Liang RenPrevost, RobertMcRae, MichaelCholleti, SharathNajarro, GabrielBuchman, Timothy G.Deem, Michael W.2014-12-152014-12-152013Chen, Man, Niestemski, Liang Ren, Prevost, Robert, et al.. "Prediction of heart rate response to conclusion of the spontaneous breathing trial by fluctuation dissipation theory." <i>Physical Biology,</i> 10, no. 1 (2013) IOP Publishing: 16006. http://dx.doi.org/10.1088/1478-3975/10/1/016006.https://hdl.handle.net/1911/78753The non-equilibrium fluctuation dissipation theorem is applied to predict how critically ill patients respond to treatment, based upon data currently collected by standard hospital monitoring devices. This framework is demonstrated on a common procedure in critical care: the spontaneous breathing trial. It is shown that the responses of groups of similar patients to the spontaneous breathing trial can be predicted by the non-equilibrium fluctuation dissipation approach. This mathematical framework, when fully formed and applied to other clinical interventions, may serve as part of the basis for personalized critical care.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.Journal articlehttp://dx.doi.org/10.1088/1478-3975/10/1/016006