2019-06-192019-06-192019-03-19Nicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S. and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US10233192B2. issued 2019-03-19. Retrieved from <a href="https://hdl.handle.net/1911/106108">https://hdl.handle.net/1911/106108</a>.https://hdl.handle.net/1911/106108In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.104engUtility patentUS10233192B2