2021-03-022021-03-022020-12-29Nicolaou, Kyriacos C., Rhoades, Derek, Wang, Yanping and Totokotsopoulos, Sotirios, "Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof." Patent US10874646B2. issued 2020-12-29. Retrieved from <a href="https://hdl.handle.net/1911/110126">https://hdl.handle.net/1911/110126</a>.https://hdl.handle.net/1911/110126"In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided. "118engUtility patentUS10874646B2