Fukuyama, Tohru2009-06-042009-06-041997Cheung, Mui. "Total synthesis of (-)-safracin B total synthesis of (-)-thiangazole development of sulfonamide chemistry." (1997) Diss., Rice University. <a href="https://hdl.handle.net/1911/19141">https://hdl.handle.net/1911/19141</a>.https://hdl.handle.net/1911/19141Chapter I describes the stereocontrolled total synthesis of ($-$)-safracin B with antibacterial and antitumor activities. The convergent approach for the synthesis of safracin B can be readily applied to the synthesis of the related isoquinolinequinone family such as saframycins and ecteinascidins. Chapter II discusses the total synthesis of ($-$)-thiangazole, a substance with potent anti-HIV-1 activity in vitro. An efficient synthetic pathway is developed to enable diverse modification of both ends of thiangazole and thus provide a rapid access to a variety of analogs. Chapter III outlines the development of new chemistry of nitrobenzenesulfonamides, N-Boc and N-Alloc nitrobenzene sulfonamides, and alkylsulfonamides for the efficient preparation of secondary amines and protected primary amines.238 p.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Organic chemistryPharmaceutical chemistryThesisTHESIS CHEM. 1997 CHEUNG