Carrejo, Nicole C.Moore, Amanda N.Lopez Silva, Tania L.Leach, David G.Li, I-CheWalker, Douglas R.Hartgerink, Jeffrey D.2019-11-222019-11-222018Carrejo, Nicole C., Moore, Amanda N., Lopez Silva, Tania L., et al.. "Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice." <i>ACS Biomaterials Science & Engineering,</i> 4, no. 4 (2018) American Chemical Society: 1386-1396. https://doi.org/10.1021/acsbiomaterials.8b00031.https://hdl.handle.net/1911/107722In vivo, multidomain peptide (MDP) hydrogels undergo rapid cell infiltration and elicit a mild inflammatory response which promotes angiogenesis. Over time, the nanofibers are degraded and a natural collagen-based extracellular matrix is produced remodeling the artificial material into natural tissue. These properties make MDPs particularly well suited for applications in regeneration. In this work, we test the regenerative potential of MDP hydrogels in a diabetic wound healing model. When applied to full-thickness dermal wounds in genetically diabetic mice, the MDP hydrogel resulted in significantly accelerated wound healing compared to a clinically used hydrogel, as well as a control buffer. Treatment with the MDP hydrogel resulted in wound closure in 14 days, formation of thick granulation tissue including dense vascularization, innervation, and hair follicle regeneration. This suggests the MDP hydrogel could be an attractive choice for treatment of wounds in diabetic patients.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical SocietyJournal articlepeptidehydrogelself-assemblydiabetic ulcerwound healingnihms952101https://doi.org/10.1021/acsbiomaterials.8b00031