Robinson, Jacob2024-01-222024-01-222023-122023-11-16December 2Parker, Matthew. "Enabling Generalized Protein Therapeutics with Implantable Bioelectronics." (2023) Master's thesis, Rice University. https://hdl.handle.net/1911/115347https://hdl.handle.net/1911/115347There are more than 10,000 proteins that make up the human proteome and errors in these proteins can have devastating effects on the body. Of these more than 10,000 proteins, only a small fraction are able to be isolated and provided as exogenous therapeutics to replace proteins that are deficient or abnormal. In this paper, we have developed an implantable bioelectronic system that works in conjunction with genetically modified cells to provide controlled doses of any native peptide to the patient. The implantable system protects the modified cells from any host immune response, accurately doses the therapeutic protein by modulating activation of the protein production by the cells, and ensures long-term cell viability for prolonged treatment in patients. In addition, the implant provides biometric feedback to help determine the effectiveness of the treatment and allows healthcare providers to adjust dosing without need for explantation.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Implantable electronicsprotein therapeuticsThesis2024-01-22