Seiler, AnninaChen, Michelle A.Brown, Ryan L.Fagundes, Christopher P.2019-12-122019-12-122018Seiler, Annina, Chen, Michelle A., Brown, Ryan L., et al.. "Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk." <i>Current Breast Cancer Reports,</i> 10, no. 1 (2018) Springer: 14-27. https://doi.org/10.1007/s12609-018-0264-0.https://hdl.handle.net/1911/107875Purpose of Review: To synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk. Recent Findings: Obesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality. Summary: Obesity increases the risk of developing breast cancer in both pre- and postmenopausal women and also negatively affects breast cancer recurrence and survival. Poor dietary habits characterized by the high intake of refined starches, sugar, and both saturated and trans-saturated fats, as well as the low intake of omega-3 fatty acids, natural antioxidants, and fiber, modulate inflammation and, thereby, appear to be linked to increased risk of breast cancer and mortality.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by SpringerJournal articleObesityNutritionDietary patternsInflammationBreast cancer riskSurvivalnihms947648https://doi.org/10.1007/s12609-018-0264-0