Synthetic studies toward the total synthesis of (+)-anthramycin total syntheses of (+)-neothramycins A and B

Fukuyama, Tohru2009-06-032009-06-031990Lin, Shao-Cheng. "Synthetic studies toward the total synthesis of (+)-anthramycin total syntheses of (+)-neothramycins A and B." (1990) Diss., Rice University. <a href="https://hdl.handle.net/1911/16364">https://hdl.handle.net/1911/16364</a>.https://hdl.handle.net/1911/16364Through the serendipitous discovery of a palladium catalyzed conversion of ethylthiol esters to their corresponding aldehydes, the pyrrolo (1,4) benzodiazepine systems found in (+)-anthramycin 1a* and (+)-neothramycins A 2a and B 2b have been constructed from the diethylthiol esters 3 and 4 respectively. A key intermediate 5 for the total synthesis of (+)-anthramycin and a facile route to (+)-neothramycins A and B are thus provided. ftn*Please refer to dissertation for diagrams.190 p.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Organic chemistryPharmaceutical chemistrySynthetic studies toward the total synthesis of (+)-anthramycin total syntheses of (+)-neothramycins A and BThesisLinSThesis Chem. 1990 Lin