Nicolaou, K.C.Shi, LeiLu, MinPattanayak, Manas R.Shah, Akshay A.Ioannidou, Heraklidia A.Lamani, Manjunath2015-10-292015-10-292014Nicolaou, K.C., Shi, Lei, Lu, Min, et al.. "Total Synthesis of Myceliothermophins C, D and E." <i>Angewandte Chemie International Edition,</i> 53, no. 41 (2014) Wiley: 10970-10974. http://dx.doi.org/10.1002/anie.201406815.https://hdl.handle.net/1911/81981The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis which revealed an interesting dimeric structure between its enantiomeric forms.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.Journal articlecascade reactiondecalinnatural productspolyketidestotal synthesishttp://dx.doi.org/10.1002/anie.201406815