Ciufolini, Marco A.2009-06-042009-06-041994Weiss, Trent Jason. "A new benzannulation reaction." (1994) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/13913">https://hdl.handle.net/1911/13913</a>.https://hdl.handle.net/1911/13913A new benzannulation reaction was discovered. The reaction involves intramolecular attack into a carbon-carbon triple-bond by the alpha position of a beta-ketoester under acidic conditions. Four different beta-ketoester starting materials were prepared and were successfully cyclized. This benzannulation methodology should provide a convenient pathway for forming aromatic products to be used as building blocks in the syntheses of anti-tumor antibiotics.95 p.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Organic chemistryThesisTHESIS CHEM. 1994 WEISS