Wang, RuohanWang, MingsaiJin, RongrongWang, YanfeiYi, MinLi, QinyeLi, JuanZhang, KaiSun, ChenghuaNie, YuHuang, ChongxiangMikos, Antonios G.Zhang, Xingdong2023-07-212023-07-212023Wang, Ruohan, Wang, Mingsai, Jin, Rongrong, et al.. "High Strength Titanium with Fibrous Grain for Advanced Bone Regeneration." <i>Advanced Science,</i> 10, no. 16 (2023) Wiley: https://doi.org/10.1002/advs.202207698.https://hdl.handle.net/1911/114970Pure titanium is widely used in clinical implants, but its bioinert properties (poor strength and mediocre effect on bone healing) limit its use under load-bearing conditions. Modeling on the structure of collagen fibrils and specific nanocrystal plane arrangement of hydroxyapatite in the natural bone, a new type of titanium (Ti) with a highly aligned fibrous-grained (FG) microstructure is constructed. The improved attributes of FG Ti include high strength (≈950 MPa), outstanding affinity to new bone growth, and tight bone-implant contact. The bone-mimicking fibrous grains induce an aligned surface topological structure conducive to forming close contact with osteoblasts and promotes the expression of osteogenic genes. Concurrently, the predominant Ti(0002) crystal plane of FG Ti induces the formation of hydrophilic anatase titanium oxide layers, which accelerate biomineralization. In conclusion, this bioinspired FG Ti not only proves to show mechanical and bone-regenerative improvements but it also provides a new strategy for the future design of metallic biomaterials.engExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.Journal article2023-Wanghttps://doi.org/10.1002/advs.202207698