Hodgson, AndreaFrow, EmmaPalmer, Xavier-LewisRohwer, ForestElcock, Leon B. IIIJohnson, AliciaZimmerman, Elise H.Voigt, Chris2025-06-032025-06-032025Hodgson, A., Frow, E., Palmer, X.-L., Rohwer, F., Elcock, L., Johnson, A., Zimmerman, E. H., & Voigt, C. (2025). 1.3 Public Infrastructure for Analyzing and Assessing Beyond Biocontainment Biotechnologies. Rice University. https://doi.org/10.25611/Z7YJ-EA10https://hdl.handle.net/1911/118549This entreaty was created as part of The Spirit of Asilomar and the Future of Biotechnology summit (February 23-26, 2025) in Pacific Grove, CA.Arising from the Biotechnologies Beyond Conventional Containment (BBCC) theme of the 2025 Spirit of Asilomar Summit, this report proposes and outlines four integrated pillars of public infrastructure for testing organisms prior to possible release into open environments. The proposed infrastructure comprises physical, digital, human and stewardship elements. It would facilitate controlled and phased experiments in a manner similar to clinical trials, allowing for the development of predictive models regarding organism dispersal, persistence, gene flow, ecological impacts and more, across various environmental scenarios. Tiered access and governance mechanisms would ideally structure testing in relation to different risk categories, and promote transparent reporting of outcomes. Such infrastructure could transform how we assess the safety and value of releasing engineered living organisms into the environment, combining real-world data and computer models to improve informed choices based on solid evidence, responsible environmental care, and public input.engThis work is protected by copyright and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.ReportSOA_2025.1.3_Public_Infrastructurehttps://doi.org/10.25611/Z7YJ-EA10https://orcid.org/0000-0003-1566-5024https://orcid.org/0000-0002-1289-5302https://orcid.org/0000-0001-8067-7182https://orcid.org/0009-0003-0003-8113https://orcid.org/0000-0002-4698-6835