2015-05-042015-05-042014-06-10Shamoo, Yousif A. and Sun, Siyang, "High processivity polymerases." Patent US8748147B2. issued 2014-06-10. Retrieved from https://hdl.handle.net/1911/80159.https://hdl.handle.net/1911/80159Chimeric proteins comprising a sequence nonspecific single-stranded nucleic-acid-binding domain joined to a catalytic nucleic-acid-modifying domain are provided. Methods comprising contacting a nucleic acid molecule with a chimeric protein, as well as systems comprising a nucleic acid molecule, a chimeric protein, and an aqueous solution are also provided. The joining of sequence nonspecific single-stranded nucleic-acid-binding domain and a catalytic nucleic-acid-modifying domain in chimeric proteins, among other things, may prevent the separation of the two domains due to their weak association and thereby enhances processivity while maintaining fidelity.18 ppengUtility patentUS8748147B2