Kim, C-YoonSikkema, William K. A.Hwang, In-KyuOh, HanseulKim, Un JengLee, Bae HwanTour, James M.2016-12-162016-12-162016Kim, C-Yoon, Sikkema, William K. A., Hwang, In-Kyu, et al.. "Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats." <i>Surgical Neurology International,</i> 7, no. Suppl 24 (2016) Surgical Neurology International: S632-S636. http://dx.doi.org/10.4103/2152-7806.190475.https://hdl.handle.net/1911/93727Background: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons. Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery. Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery. Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord.engThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.Journal articleCephalosomatic anastomosiselectrophysiologygraphene nanoribbonsGEMINIspinal cord fusionhttp://dx.doi.org/10.4103/2152-7806.190475