Shah, Kamal G.Guelig, DylanDiesburg, StevenBuser, JoshuaBurton, RobertLaBarre, PaulRichards-Kortum, RebeccaWeigl, Bernhard2016-04-012016-04-012015Shah, Kamal G., Guelig, Dylan, Diesburg, Steven, et al.. "Design of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification." <i>PLoS ONE,</i> 10, no. 10 (2015) Public Library of Science: e0139449. http://dx.doi.org/10.1371/journal.pone.0139449.https://hdl.handle.net/1911/88823Previous chemical heater designs for isothermal nucleic acid amplification have been based on solid-liquid phase transition, but using this approach, developers have identified design challenges en route to developing a low-cost, disposable device. Here, we demonstrate the feasibility of a new heater configuration suitable for isothermal amplification in which one reactant of an exothermic reaction is a liquid-gas phase-change material, thereby eliminating the need for a separate phase-change compartment. This design offers potentially enhanced performance and energy density compared to other chemical and electric heaters.engThis is an open access article distributed under the terms of the�Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedJournal articlehttp://dx.doi.org/10.1371/journal.pone.0139449