Shin, JaeohKolomeisky, Anatoly B.2019-01-182019-01-182018Shin, Jaeoh and Kolomeisky, Anatoly B.. "Molecular search with conformational change: One-dimensional discrete-state stochastic model." <i>The Journal of Chemical Physics,</i> 149, no. 17 (2018) AIP Publishing LLC: https://doi.org/10.1063/1.5051035.https://hdl.handle.net/1911/105101Molecular search phenomena are observed in a variety of chemical and biological systems. During the search, the participating particles frequently move in complex inhomogeneous environments with random transitions between different dynamic modes. To understand the mechanisms of molecular search with alternating dynamics, we investigate the search dynamics with stochastic transitions between two conformations in a one-dimensional discrete-state stochastic model. It is explicitly analyzed using the first-passage time probability method to obtain a full dynamic description of the search process. A general dynamic phase diagram is developed. It is found that there are several dynamic regimes in the molecular search with conformational transitions, and they are determined by the relative values of the relevant length scales in the system. Theoretical predictions are fully supported by Monte Carlo computer simulations.engArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.Journal articlehttps://doi.org/10.1063/1.5051035