Lu, MingyangOnuchic, JoséBen-Jacob, Eshel2014-09-302014-09-302014Lu, Mingyang, Onuchic, José and Ben-Jacob, Eshel. "Construction of an Effective Landscape for Multistate Genetic Switches." <i>Physical Review Letters,</i> 113, (2014) American Physical Society: 78102. http://dx.doi.org/10.1103/PhysRevLett.113.078102.https://hdl.handle.net/1911/77317Multistate genetic switches play a crucial role during embryonic development and tumorigenesis. An archetypical example is the three-way switch regulating epithelial-hybrid-mesenchymal transitions. We devise a special WKB-based approach to investigate white Gaussian and shot noise effects on three-way switches, and construct an effective landscape in good quantitative agreement with stochastic simulations. This approach allows efficient analytical or numerical calculation of the landscape contours, the optimal path, and the state relative stability for general multicomponent multistate switches.engArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.Journal articlehttp://dx.doi.org/10.1103/PhysRevLett.113.078102