Robinson, Jacob2021-05-032021-11-012021-052021-04-29May 2021Singer, Amanda. "Magnetoelectric Materials for Wireless Power Delivery to Miniature Bioelectronic Implants." (2021) Diss., Rice University. <a href="https://hdl.handle.net/1911/110434">https://hdl.handle.net/1911/110434</a>.https://hdl.handle.net/1911/110434Advances in implanted bioelectronic technology offers the opportunity to develop more effective tools for personalized electronic medicine. While there are numerous clinical and pre-clinical applications for these devices, power delivery to these systems can be challenging. Wireless battery-free devices offer advantages such as a smaller and lighter device footprint and reduced failures and infections by eliminating lead wires. However, with the development of wireless technologies, there are fundamental tradeoffs between five essential factors: power, miniaturization, depth, alignment tolerance, and transducer distance, while still allowing devices to work within safety limits. Here I briefly discuss five existing types of wireless power transfer technologies used in bioelectronic implants - inductive coupling, radio frequency, mid-field, ultrasound, and light -and review them in context of the five tradeoffs listed above. I then add a new alternative wireless power method based on magnetoelectric (ME) materials which combines the advantages of ultrasound and inductive coupling (miniature devices activated from a distance away) to deliver therapeutic stimulation in excess of 100 Hz. I demonstrate that wireless ME stimulators provide deep brain stimulation in a freely moving rodent model for Parkinson’s disease and that these devices can be miniaturized to mm-scale and fully implanted. These results suggest ME materials are an excellent candidate to add to the fundamental types of wireless power techniques and enable miniature bioelectronics for clinical and research applications is situations where other types of wireless power transfer may be limited.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.MagnetoelectricBioelectronicThesis2021-05-03