Raoof, MustafaCisneros, Brandon T.Guven, AdemCorr, Stuart J.Wilson, Lon J.Curley, Steven A.2015-07-102015-07-102013Raoof, Mustafa, Cisneros, Brandon T., Guven, Adem, et al.. "Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields." <i>Biomaterials,</i> 34, no. 7 (2013) Elsevier: 1862-1869. http://dx.doi.org/10.1016/j.biomaterials.2012.11.033.https://hdl.handle.net/1911/80882The efficacy of nanoparticle-mediated drug delivery is limited by its peri-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.Journal articleradiofrequency fieldcarbon nanotubesUS-tubestriggered releaseliver cancercisplatinhttp://dx.doi.org/10.1016/j.biomaterials.2012.11.033