2020-09-152020-09-152020-03-17Nicolaou, Kyriacos C., Li, Ruofan, Lu, Zhaoyong, Sohn, Te-ik, Woods, James and Pitsinos, Emmanouil N., "Total synthesis of shishijimicin A and analogs thereof." Patent US10590158B2. issued 2020-03-17. Retrieved from <a href="https://hdl.handle.net/1911/109345">https://hdl.handle.net/1911/109345</a>.https://hdl.handle.net/1911/109345In one aspect, the present disclosure provides shishijimicin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, antibody drug conjugates of the compounds are also provided.163engUtility patentUS10590158B2