Frey, Eric W.Gooding, Ashton A.Wijeratne, SitaraKiang, Ching-Hwa2014-12-152014-12-152012Frey, Eric W., Gooding, Ashton A., Wijeratne, Sitara, et al.. "Understanding the physics of DNA using nanoscale single-molecule manipulation." <i>Frontiers of Physics,</i> 7, no. 5 (2012) Springer: 576-581. http://dx.doi.org/10.1007/s11467-012-0261-0.https://hdl.handle.net/1911/78756Processes for decoding the genetic information in cells, including transcription, replication, recombination and repair, involve the deformation of DNA from its equilibrium structures such as bending, stretching, twisting, and unzipping of the double helix. Single-molecule manipulation techniques have made it possible to control DNA conformation and simultaneously detect the induced changes, revealing a rich variety of mechanically-induced conformational changes and thermodynamic states. These single-molecule techniques helped us to reveal the physics of DNA and the processes involved in the passing on of the genetic code.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Springer.Journal articlesingle-molecule manipulationphysics of DNAhttp://dx.doi.org/10.1007/s11467-012-0261-0