Hernández-Rivera, MayraCho, Stephen Y.Moghaddam, Sakineh E.Cheong, Benjamin Y.Cabreira-Hansen, Maria da GraçaWillerson, James T.Perin, Emerson C.Wilson, Lon J.2019-09-172019-09-172019Hernández-Rivera, Mayra, Cho, Stephen Y., Moghaddam, Sakineh E., et al.. "Labeling Stem Cells with a New Hybrid Bismuth/Carbon Nanotube Contrast Agent for X-Ray Imaging." <i>Contrast Media & Molecular Imaging,</i> 2019, (2019) Hindawi: https://doi.org/10.1155/2019/2183051.https://hdl.handle.net/1911/107411The poor retention and survival of cells after transplantation to solid tissue represent a major obstacle for the effectiveness of stem cell-based therapies. The ability to track stem cells in vivo can lead to a better understanding of the biodistribution of transplanted cells, in addition to improving the analysis of stem cell therapies’ outcomes. Here, we described the use of a carbon nanotube-based contrast agent (CA) for X-ray computed tomography (CT) imaging as an intracellular CA to label bone marrow-derived mesenchymal stem cells (MSCs). Porcine MSCs were labeled without observed cytotoxicity. The CA consists of a hybrid material containing ultra-short single-walled carbon nanotubes (20–80 nm in length, US-tubes) and Bi(III) oxo-salicylate clusters which contain four Bi3+ ions per cluster (Bi4C). The CA is thus abbreviated as Bi4C@US-tubes.engThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Journal article2183051https://doi.org/10.1155/2019/2183051