Kang, DonghoonKirienko, Daniel R.Webster, PhillipFisher, Alfred L.Kirienko, Natalia V.2018-08-172018-08-172018Kang, Donghoon, Kirienko, Daniel R., Webster, Phillip, et al.. "Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response." <i>Virulence,</i> 9, no. 1 (2018) Taylor & Francis: 804-817. https://doi.org/10.1080/21505594.2018.1449508.https://hdl.handle.net/1911/102464Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.engThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Journal articleCaenorhabditis elegansPseudomonas aeruginosahost responsemitochondrial damagepathogenesispyoverdinesiderophorePyoverdinehttps://doi.org/10.1080/21505594.2018.1449508