2021-03-022021-03-022020-12-08Ho, Michelle, Suh, Junghae, Yamagami, Momona, Gough, Veronica and Kang, Byunguk, "Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses." Patent US10858630B2. issued 2020-12-08. Retrieved from <a href="https://hdl.handle.net/1911/110125">https://hdl.handle.net/1911/110125</a>.https://hdl.handle.net/1911/110125The present disclosure provide viral compositions and methods for modulating adeno-associated virus properties including transduction efficiency, virus capsid assembly, viral genome packaging, capsid stability and intracellular processing. Engineered adeno-associated viruses with modifications in the N-terminal region of the capsid proteins VP1 or VP2 are provided which have varying effects on viral properties including transduction efficiency. Corresponding nucleic acids and amino acids are provided.95engUtility patentUS10858630B2