Mamidi, NarsimhaVelasco Delgadillo, Ramiro ManuelGonzáles Ortiz, AldoBarrera, Enrique V.2021-02-082021-02-082020Mamidi, Narsimha, Velasco Delgadillo, Ramiro Manuel, Gonzáles Ortiz, Aldo, et al.. "Carbon Nano-Onions Reinforced Multilayered Thin Film System for Stimuli-Responsive Drug Release." <i>Pharmaceutics,</i> 12, no. 12 (2020) MDPI: https://doi.org/10.3390/pharmaceutics12121208.https://hdl.handle.net/1911/109823Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs) and anilinated-poly (ether ether ketone) (AN-PEEK) have synthesized, and AN-PEEK/f-CNOs composite thin films were primed via layer-by-layer (LbL) self-assembly for stimuli-responsive drug release. The obtained thin films exhibited pH-responsive drug release in a controlled manner; pH 4.5 = 99.2% and pH 6.5 = 59.3% of doxorubicin (DOX) release was observed over 15 days. Supramolecular π-π stacking interactions between f-CNOs and DOX played a critical role in controlling drug release from thin films. Cell viability was studied with human osteoblast cells and augmented viability was perceived. Moreover, the thin films presented 891.4 ± 8.2 MPa of the tensile strength (σult), 43.2 ± 1.1 GPa of Young’s modulus (E), and 164.5 ± 1.7 Jg−1 of toughness (K). Quantitative scrutiny revealed that the well-ordered aligned nanofibers provide critical interphase, and this could be responsible for augmented tensile properties. Nonetheless, a pH-responsive and mechanically robust biocompatible thin-film system may show potential applications in the biomedical field.engThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedJournal articlenanocomposite thin filmslayer-by-layer assemblystrengthYoung’s modulustoughnesspH-responsive drug releasecell viabilitypharmaceutics-12-01208-v2https://doi.org/10.3390/pharmaceutics12121208