Sinkevich, OlenaTapia, Richard A.Zhang, YinLudtke, Steven J.2018-06-182018-06-182000-08Sinkevich, Olena, Tapia, Richard A., Zhang, Yin, et al.. "Simultaneous Structure Factor and Contrast Transfer Function Parameter Determination in Transmission Electron Microscopy." (2000) <a href="https://hdl.handle.net/1911/101954">https://hdl.handle.net/1911/101954</a>.https://hdl.handle.net/1911/101954We present a new method that allows a fully automated simultaneous determination of the structure factor and the parameters of the Contrast Transfer Function (CTF) and noise function. No previous knowledge of the structure factor or of the CTF parameters is assumed. Our approach is based on the new precise mathematical formulations of the problem as constrained nonlinear least squares that treats the structure factor as a set of undetermined variables, as well as the CTF parameters, and on the interior-point algorithm that satisfies the inequality constraints on the bounds.21 ppengTechnical reportTR00-26