McIntire, Larry V.2009-06-042009-06-041992Natarajan, Maya. "Effect of novel antithrombotic agents on platelet aggregation under flow conditions." (1992) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/13602">https://hdl.handle.net/1911/13602</a>.https://hdl.handle.net/1911/13602Epi-fluorescence video microscopy and digital image processing were used to evaluate the effects of three novel anti-platelet agents namely GT-12/I.2HBr (GT-12/I), A4.2HBr and IC, a series of compounds containing the $-$3-carboxylic acid piperidine moiety as their functional group, on platelet aggregation. GT-12/I was evaluated at a concentration of 100$\mu$M so that it could be used as a reference compound against which the effects of A4.2HBr and IC could be compared. Results show that at this concentration GT-12/I inhibited platelet accumulation by 59.0 $\pm$ 3.8% whereas A4.2HBr, the more hydrophobic molecule, inhibited aggregation by 73.5 $\pm$ 1.9% at the same concentration. This confirms earlier predictions that the optimization of hydrophobicity within a compound maximizes its inhibitory potential. Stereochemistry, however, seems to dominate over all other effects as it was observed that IC, an enantiomer of GT-12/I, drastically reduced platelet aggregation by 84.8 $\pm$ 2.8%. (Abstract shortened with permission of author.)81 p.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Biomedical engineeringChemical engineeringThesisThesis Ch.E. 1992 Natarajan