Kemere, Caleb2019-05-172019-05-172018-082018-08-10August 201Lewis, Eric. "Rodent deep brain stimulation hardware and mechanisms." (2018) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/105744">https://hdl.handle.net/1911/105744</a>.https://hdl.handle.net/1911/105744This thesis developed an inexpensive, wirelessly programmable deep brain stimulator to evaluate novel stimulation patterns in rodent Parkinson’s Disease (PD). Current deep brain stimulators for Parkinson’s patients only benefit two-thirds of people implanted. The need to develop more effective treatments for Parkinson’s inspired genetic disease models to study the mechanisms of the disease. Stimulators for rodent models exist but can be improved. The head-mounted stimulator in this thesis builds on prior designs through Near Field Communication (NFC) to program stimulator settings. Additionally, the stimulator can provide uniformly distributed offsets to pulse times called ”jitter.” The stimulator efficacy was evaluated in 6- Hydroxydopamine (OHDA) rats through methamphetamine induced rotation studies. High Frequency Stimulation (HFS) corrected ipsilateral rotation and induced transient contralateral rotation in agreement with prior behavioral studies. With this open source hardware, labs can implement novel deep brain stimulation patterns chronically in new disease models to improve stimulation performance for Parkinson’s.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.MSP430rodent6-OHDAirregularstimulationNFCThesis2019-05-17