Salter, Mallory D.Blouin, George C.Soman, JayashreeSingleton, Eileen WilleyDewilde, SylviaMoens, LucPesce, AlessandraNardini, MarcoBolognesi, MartinoOlson, John S.2013-03-212014-03-222012Salter, Mallory D., Blouin, George C., Soman, Jayashree, et al.. "Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates." <i>The Journal of Biological Chemistry,</i> 287, no. 40 (2012) The American Society for Biochemistry and Molecular Biology, Inc.: 33163-33178. http://dx.doi.org/10.1074/jbc.M112.392258.https://hdl.handle.net/1911/70807Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental benchmarks for testing molecular dynamics simulations. Significance: Globins can use either a polar gate or an apolar tunnel for ligand entry.engArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.Journal articlehttp://dx.doi.org/10.1074/jbc.M112.392258