2015-05-042015-05-042007-07-03Matsuda, Seiichi P. T. and Hart, Elizabeth A., "Diterpene-producing unicellular organism." Patent US7238514B2. issued 2007-07-03. Retrieved from https://hdl.handle.net/1911/79942.https://hdl.handle.net/1911/79942The present invention is directed to a unicellular organism system, such as a yeast, for producing geranylgeranyl pyrophosphate and a diterpene in vivo. The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synthase, an inducible nucleic acid sequence encoding a soluble form of HMG-CoA reductase, a nucleic acid sequence of an allele that confers an increase in sterol metabolic flux and, in the diterpene-producing cell, a diterpene synthase.36 ppengUtility patentUS7238514B2