Gautam, ChandkiramChakravarty, DibyenduGautam, AmarendraTiwary, Chandra SekharWoellner, Cristiano FranciscoMishra, Vijay KumarAhmad, NaseerOzden, SehmusJose, SujinBiradar, SantoshkumarVajtai, RobertTrivedi, RituGalvao, Douglas S.Ajayan, Pulickel M.2018-08-212018-08-212018Gautam, Chandkiram, Chakravarty, Dibyendu, Gautam, Amarendra, et al.. "Synthesis and 3D Interconnected Nanostructured h-BN-Based Biocomposites by Low-Temperature Plasma Sintering: Bone Regeneration Applications." <i>ACS Omega,</i> 3, no. 6 (2018) American Chemical Society: 6013-6021. https://doi.org/10.1021/acsomega.8b00707.https://hdl.handle.net/1911/102483Recent advances and demands in biomedical applications drive a large amount of research to synthesize easily scalable low-density, high-strength, and wear-resistant biomaterials. The chemical inertness with low density combined with high strength makes h-BN one of the promising materials for such application. In this work, three-dimensional hexagonal boron nitride (h-BN) interconnected with boron trioxide (B2O3) was prepared by easily scalable and energy efficient spark plasma sintering (SPS) process. The composite structure shows significant densification (1.6–1.9 g/cm3) and high surface area (0.97–14.5 m2/g) at an extremely low SPS temperature of 250 °C. A high compressive strength of 291 MPa with a reasonably good wear resistance was obtained for the composite structure. The formation of strong covalent bonds between h-BN and B2O3 was formulated and established by molecular dynamics simulation. The composite showed significant effect on cell viability/proliferation. It shows a high mineralized nodule formation over the control, which suggests its use as a possible osteogenic agent in bone formation.engThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.Journal articleacsomega.8b00707https://doi.org/10.1021/acsomega.8b00707