Thomas, Chris S.Braun, Doug R.Olmos, Jose Luis Jr.Rajski, Scott R.Phillips, George N.Jr.Andes, David N.Bugni, Tim S.2020-10-162020-10-162020Thomas, Chris S., Braun, Doug R., Olmos, Jose Luis Jr., et al.. "Pyridine-2,6-Dithiocarboxylic Acid and Its Metal Complexes: New Inhibitors of New Delhi Metallo -Lactamase-1." <i>Marine Drugs,</i> 18, no. 6 (2020) MDPI: https://doi.org/10.3390/md18060295.https://hdl.handle.net/1911/109422Carbapenem-resistant Enterobacteriaceae continue to threaten human health worldwide with few effective treatment options. New Delhi metallo--lactamase (NDM) enzymes are a contributing element that drive resistance to many -lactam- and carbapenem-based antimicrobials. Many NDM inhibitors are known, yet none are clinically viable. In this study, we present and characterize a new class of NDM-1 inhibitors based on a pyridine-2,6-dithiocarboxylic acid metal complex scaffold. These complexes display varied and unique activity profiles against NDM-1 in kinetic assays and serve to increase the effectiveness of meropenem, an established antibacterial, in assays using clinical Enterobacteriaceae isolates.engThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedJournal articleNDM-1 inhibitorsmarine-derived Streptomyces sp.carbapenem-resistant Enterobacteriaceaemetal chelatorshttps://doi.org/10.3390/md18060295