Cheng, ChunweiLiu, YanBalasis, Maria E.Simmons, Nicholas L.Li, JerrySong, HaoPan, LiliQin, YongNicolaou, K.C.Sebti, Said M.Li, Rongshi2017-08-042017-08-042014Cheng, Chunwei, Liu, Yan, Balasis, Maria E., et al.. "Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim." <i>Marine Drugs,</i> 12, no. 3 (2014) MDPI: 1335-1348. https://doi.org/10.3390/md12031335.https://hdl.handle.net/1911/96582A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is two-fold more potent than 1. Two novel cyclic marinopyrroles (3 and 4) are two- to seven-fold more potent than 1.engThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution licenseJournal articlecyclic marinopyrrolesprotein-protein interaction disruptorsapoptosisSARCyclic_Marinopyrrole_Derivativeshttps://doi.org/10.3390/md12031335