2026-09-20T20:41:56Zhttps://repository.rice.edu/server/oai/request

oai:repository.rice.edu:1911/187222024-01-11T20:58:22Zcom_1911_8299col_1911_13110

Clark, John W., Jr. Yang, Jin 2009-06-04T06:41:30Z 2009-06-04T06:41:30Z 2004 Yang, Jin. "Modeling vascular smooth muscle contraction." (2004) Diss., Rice University. <a href="https://hdl.handle.net/1911/18722">https://hdl.handle.net/1911/18722</a>. https://hdl.handle.net/1911/18722 THESIS E.E. 2004 YANG This thesis work presents a multi-scale mathematical modeling framework to investigate issues regarding vascular smooth muscle contraction. The overall structure of this thesis consists of (1) a model of single vascular smooth muscle cell membrane electrophysiology, contractile system kinetics and cell mechanics; (2) a model of signal transduction of nitric-oxide induced vascular smooth muscle relaxation, and (3) a cellular-based model for myogenic responses of isolated arteries. These models present a general and comprehensive description of VSM contraction and its associated signal transduction, which integrates information from both microscopic (cellular and subcellular interactions) and macroscopic (isolated vessel) levels. These models were utilized to investigate many underlying principles of vascular smooth muscle contraction mediated by multiple signaling pathways and can be applied to study functions of vascular smooth muscle under a variety of physiological and pathological conditions. 134 p. application/pdf eng Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder. Biomedical engineering Biophysics Modeling vascular smooth muscle contraction Thesis Text Electrical Engineering Engineering Rice University Doctoral Doctor of Philosophy open.access