Shear stress effects on epithelium cell cultures in vitro

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dc.contributor.advisorHellums, Jesse D.
dc.contributor.committeeMemberArmeniades, C. D.
dc.contributor.committeeMemberMcIntire, Larry V.
dc.creatorStathopoulos, Nikos A.
dc.date.accessioned2018-12-18T21:18:02Z
dc.date.available2018-12-18T21:18:02Z
dc.date.issued1983
dc.descriptionNo pages 104-105, 116-117, 126-127
dc.description.abstractThis study aims to determine the influence of shear stress on cell cultures under carefully controlled conditions. Human embryonic kidney cells grow^as an attached, confluent monolayer on a flat substrate were subjected to steady, uniform laminar flow in a specially designed flow chamber, in which shear stress was precisely defined and controlled. Experiments performed for shear stresses ranging from .2 to 6. N/m, with a varied shear stress exposure time from 2 to 24 hours. The influence of the shear field was slight at low shear stress (.26 N/m) but it had a dramatic effect on cell morphology at higher shear stresses (above 2.6 N/m ) and long exposure times (24 hours). It was also found that shear stress and time stimulated the release of urokinase enzyme. The significance of such flow studies is presented in relation to their possible use for biosynthesis of urokinase enzyme by kidney epithelial cells/
dc.format.digitalOriginreformatted digital
dc.format.extent137 pp
dc.identifier.callnoTHESIS CH.E. 1983 STATHOPOULOS
dc.identifier.citationStathopoulos, Nikos A.. "Shear stress effects on epithelium cell cultures in vitro." (1983) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/104151">https://hdl.handle.net/1911/104151</a>.
dc.identifier.digitalRICE1778
dc.identifier.urihttps://hdl.handle.net/1911/104151
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.titleShear stress effects on epithelium cell cultures in vitro
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemical Engineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
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