Magnetoelectric Bio-Implants Powered and Programmed by a Single Transmitter for Coordinated Multisite Stimulation
| dc.contributor.advisor | Yang, Kaiyuan | |
| dc.creator | Yu, Zhanghao | |
| dc.date.accessioned | 2022-09-29T15:21:28Z | |
| dc.date.available | 2022-09-29T15:21:28Z | |
| dc.date.created | 2022-05 | |
| dc.date.issued | 2022-01-14 | |
| dc.date.submitted | May 2022 | |
| dc.date.updated | 2022-09-29T15:21:28Z | |
| dc.description.abstract | Coordinated multisite biomedical stimulations have shown exciting promise in clinical therapies, such as applications in heart and spinal cord. To reduce infection risks, surgery complexity, and restrictions in subject mobility, implants need to be miniature and untethered. Moreover, for coordinated multisite stimulation, the system should flexibly deploy stimuli without leads, synchronize operation of all the implants, and freely scale the stimulation channel quantity. While significant progress has been made to develop bio-implants for multisite stimulation, existing approaches fail to simultaneously deliver these desired properties. In this thesis, we propose a hardware platform including mm-sized stimulating implants magnetoelectrically powered and individually programmed by a shared transmitter. The proposed novel single-transmitter, multiple-implant structure realizes more flexible stimuli deployment, easier synchronization of device operation, higher system efficiency, and improved scalability of stimulation channels. Magnetoelectric effects are leveraged to build the wireless power and downlink data links in this work, because of the good efficiency under receiver size constraints, low misalignment sensitivity and low tissue absorption. Magnetoelectric power transfer is capable of safely transmitting milliwatt power to devices placed several centimeters away from the transmitter coil, maintaining good efficiency with size constraints, tolerating 60-degree, 1.5-cm misalignment in angular and lateral movement, and supporting multiple receiver devices without increasing the transmitter power. The robust and efficient system-on-chip design enables the implants to operate reliably with a 2-V source amplitude change, tolerating a 40-mm transmitter-implant distance variation and 50-degree angular misalignment, 1.5-cm lateral misalignment at a 3-cm implantation depth. The implants achieve individual programming through physical unclonable function IDs and generates synchronized stimulation with a maximum efficiency of 90% and fully programmable stimulation patterns including amplitude, pulse width, shape, and delay. These key features bring great advantages to the proposed technique for clinical treatments. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.citation | Yu, Zhanghao. "Magnetoelectric Bio-Implants Powered and Programmed by a Single Transmitter for Coordinated Multisite Stimulation." (2022) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/113453">https://hdl.handle.net/1911/113453</a>. | |
| dc.identifier.uri | https://hdl.handle.net/1911/113453 | |
| dc.language.iso | eng | |
| dc.rights | Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder. | |
| dc.subject | Wireless biomedical stimulator | |
| dc.subject | multisite bio-stimulation | |
| dc.subject | implantable device | |
| dc.subject | bio-electronics | |
| dc.subject | magnetoelectric effect | |
| dc.subject | wireless power transfer. | |
| dc.title | Magnetoelectric Bio-Implants Powered and Programmed by a Single Transmitter for Coordinated Multisite Stimulation | |
| dc.type | Thesis | |
| dc.type.material | Text | |
| thesis.degree.department | Electrical and Computer Engineering | |
| thesis.degree.discipline | Engineering | |
| thesis.degree.grantor | Rice University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science |
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