Evidence for nuclear internalisation of biocompatible [60]fullerene1)

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dc.citation.firstpage51en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitleEuropean Journal of Nanomedicineen_US
dc.citation.lastpage55en_US
dc.citation.volumeNumber5en_US
dc.contributor.authorHuang, Feiranen_US
dc.contributor.authorMackeyev, Yurien_US
dc.contributor.authorWatson, Erinen_US
dc.contributor.authorCheney, Matthew A.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.authorSuh, Junghaeen_US
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2016-01-29T16:52:04Zen_US
dc.date.available2016-01-29T16:52:04Zen_US
dc.date.issued2013en_US
dc.description.abstractMany types of nanoparticles (NPs) have been shown to internalise within mammalian cells (1), but only a few have been observed to internalise within the cell nucleus-most likely due to the tightly-regulated nuclear membrane (2). Internalisation of NPs into the nucleus is desirable for several reasons, including their use as 1. transfection agents (3), 2. drug delivery platforms for drugs that act on DNA (4), and 3. hyperthermia-inducing agents for cancer therapy using non-invasive stimulation by radiofrequency irradiation (5), magnetic-field cycling (6), or photonic activation (7). For example, derivatised NPs, including protein-functionalised quantum dots (8) and peptide-functionalised gold NPs (9), have been shown to internalise into the nucleus. For underivatised NPs, single-walled carbon nanotubes (SWNTs), have been observed by direct transmission electron microscopy (TEM) imaging to also localise in the nucleus of human macrophage cells with dose-dependent cytotoxicity (10). Fullerene C60ﾠis another classic carbon-based NP, however it was not been shown to enter the cell nucleus until recently. In particular, a water soluble derivative of C60ﾠfluorescently labelled with a small molecule fluorophore was shown to enter cell nuclei through nuclear pore complexes in liver cancer cells (11). Here, we validate the nuclear internalisation ability of the C60derivative in several other cell types, further supporting the unique intracellular biodistribution property of this specific fullerene compound.en_US
dc.identifier.citationHuang, Feiran, Mackeyev, Yuri, Watson, Erin, et al.. "Evidence for nuclear internalisation of biocompatible [60]fullerene1)." <i>European Journal of Nanomedicine,</i> 5, no. 1 (2013) Walter de Gruyter GmbH: 51-55. http://dx.doi.org/10.1515/ejnm-2012-0009.en_US
dc.identifier.doihttp://dx.doi.org/10.1515/ejnm-2012-0009en_US
dc.identifier.urihttps://hdl.handle.net/1911/88256en_US
dc.language.isoengen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordcolocalisationen_US
dc.subject.keywordconfocal microscopyen_US
dc.subject.keywordfluorophoreen_US
dc.subject.keywordfullereneen_US
dc.subject.keywordnucleusen_US
dc.titleEvidence for nuclear internalisation of biocompatible [60]fullerene1)en_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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