Pre-clinical Characterization of Tissue Engineering Constructs for Bone and Cartilage Regeneration

Simple item page
dc.citation.firstpage681en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleAnnals of Biomedical Engineeringen_US
dc.citation.lastpage696en_US
dc.citation.volumeNumber43en_US
dc.contributor.authorTrachtenberg, Jordan E.en_US
dc.contributor.authorVo, Tiffany N.en_US
dc.contributor.authorMikos, Antonios G.en_US
dc.date.accessioned2017-05-22T18:57:18Zen_US
dc.date.available2017-05-22T18:57:18Zen_US
dc.date.issued2015en_US
dc.description.abstractPre-clinical animal models play a crucial role in the translation of biomedical technologies from the bench top to the bedside. However, there is a need for improved techniques to evaluate implanted biomaterials within the host, including consideration of the care and ethics associated with animal studies, as well as the evaluation of host tissue repair in a clinically relevant manner. This review discusses non-invasive, quantitative, and real-time techniques for evaluating host-materials interactions, quality and rate of neotissue formation, and functional outcomes of implanted biomaterials for bone and cartilage tissue engineering. Specifically, a comparison will be presented for pre-clinical animal models, histological scoring systems, and non-invasive imaging modalities. Additionally, novel technologies to track delivered cells and growth factors will be discussed, including methods to directly correlate their release with tissue growth.en_US
dc.identifier.citationTrachtenberg, Jordan E., Vo, Tiffany N. and Mikos, Antonios G.. "Pre-clinical Characterization of Tissue Engineering Constructs for Bone and Cartilage Regeneration." <i>Annals of Biomedical Engineering,</i> 43, no. 3 (2015) Springer: 681-696. http://dx.doi.org/10.1007/s10439-014-1151-0.en_US
dc.identifier.doihttp://dx.doi.org/10.1007/s10439-014-1151-0en_US
dc.identifier.urihttps://hdl.handle.net/1911/94333en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Springer.en_US
dc.titlePre-clinical Characterization of Tissue Engineering Constructs for Bone and Cartilage Regenerationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
tissue-engineering-constructs.pdf
Size:
695.94 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Bioengineering Publications